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PROBAST: An opportunity to pilot test a new risk of bias tool for prediction modelling studies

Date and Location




Friday 20 September 2013 - 13:30 - 15:00
Contact persons and facilitators

Contact person

Robert Wolff


Robert Wolff
Karel Moons
Sue Mallett
Penny Whiting
Jos Kleijnen
Other contributors
First nameLast nameAffiliation and Country

First name


Last name


Affiliation and Country

School of Health and Population Sciences, and School of Mathematics, University of Birmingham, UK

First name


Last name


Affiliation and Country

Kleijnen Systematic Reviews Ltd, UK
Target audience

Target audience

Authors conducting systematic reviews of prediction studies

Is your workshop restricted to a specific audience or open to all Colloquium participants?


Level of knowledge required

Type of workshop

Type of workshop

Abstract text


Objectives: Quality assessment of included studies is a crucial step in any systematic review. Review and synthesis of prediction modelling studies is a relatively new and evolving area. The QUIPS tool for prediction finding studies has been recently updated. However, a tool facilitating quality assessment for prognostic and diagnostic prediction modelling studies is needed. We are currently developing PROBAST, a tool for assessing the risk of bias and applicability of prediction modelling studies. Description: The workshop will be split into two sessions. The first session will be an overview of the development and structure of PROBAST. We have used a Delphi process, including thirty-nine experts in the field of prediction research. Feedback from the first rounds of our survey suggests that a domain-based approach similar to that implemented in QUADAS-2 will be used. The presentation will give an overview of the process, the current version of the tool (including the domains covered and signalling questions) as well as an insight into underlying discussions. In the second half of the workshop, participants will have the opportunity to discuss and pilot-test PROBAST. Feedback gathered during the workshop will contribute to the evaluation, and possible revision, of PROBAST.