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Calculation and interpretation of the number needed to treat (NNT)

Date and Location

Session: 

W1.09

Date: 

Friday 20 September 2013 - 10:30 - 12:00

Location

Methods Group and core training

Methods Group

Statistical Methods Group
Contact persons and facilitators

Contact person

Ralf Bender

Facilitators

Ralf Bender
Target audience

Target audience

Review authors, editors and referees

Is your workshop restricted to a specific audience or open to all Colloquium participants?

Open

Level of knowledge required

Basic
Type of workshop

Type of workshop

Training
Abstract text

Abstract

Objectives: To provide review authors with the knowledge and skills needed to calculate NNTs from trial reports and Summary of Findings (SoF) tables of Cochrane reviews; to verify whether reported NNTs are adequate and to interpret the results. Description: The number needed to treat (NNT) is widely used to present the results of clinical trials. However, incorrect calculations, misuse in specific study situations and misleading interpretation of NNTs are not uncommon in practice, for example in the case of non-significant results or in the situation of survival time data. This workshop will provide an introduction to the use and interpretation of NNTs as effect measure in clinical trials and systematic reviews. It will be shown how to calculate NNTs with corresponding confidence intervals from Summary of Findings (SoF) tables. We will discuss in particular the limitations of NNTs including problems associated with the inconvenient scale, the sensitivity to changes of the baseline risk and the dependence on the follow-up time. Small group practical work will be an integral part of the workshop focusing on adequate calculation and interpretation of point and interval estimates of NNTs in practical examples. Participants should bring pocket calculators, pens and paper.